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March 15, 2013

Combination of stem cell therapy and physical therapy can reverse the effects of spinal cord injury

Walking is the obvious goal for individuals who have a chronic spinal cord injury, but it is not the only one. Regaining sensation and continence control also are important goals that can positively impact an individual’s quality of life. New hope for reversing the effects of spinal cord injury may be found in a combination of stem cell therapy and physical therapy as reported in Cell Transplantation by scientists at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School. (News-Medical)

March 14, 2013

Adult stem cell treatment for diabetic wounds

Pre-clinical research has generated some very promising findings using adult stem cells for the treatment of diabetic wounds. The research carried out by scientists at the National University of Ireland Galway, is published in Diabetes, the official journal of the American Diabetes Association. (News-Medical)

Painkillers could prove helpful in stem-cell transplants

Aspirin-like drugs could improve the success of stem-cell transplants for patients with blood or bone-marrow disorders, a study suggests. The compounds coax stem cells from bone marrow into the bloodstream where they can be harvested for use in transplantation — and they do so with fewer side effects than drugs now in use. (Scientific American)

March 11, 2013

Time to ditch stand-alone cell overisight panels, experts say

To encourage responsible practices, the US National Academies issued a report in 2005 calling for the establishment of stand-alone institutional oversight committees, and within two years, at least 25 so-called ‘embryonic stem cell research oversight committees’, or ESCROs, cropped up across the country. (Nature)

Stem cells point to origin of deadly ovarian cancer

An aggressive form of ovarian cancer most likely originates in stem cells located in a layer of tissue that links the ovary to the rest of the body. (Futurity)

Signalling molecule may help stem cells focus on making bone despite age, disease

A signaling molecule that helps stem cells survive in the naturally low-oxygen environment inside the bone marrow may hold clues to helping the cells survive when the going gets worse with age and disease, researchers report. (Science Daily)

March 8, 2013

Stem cell therapies closer to clinic

group of researchers in the United States and South Korea has announced a leap towards safe, clinically useful patient-specific stem cells. If the researchers are right, clinical trials on the induced pluripotent stem (iPS) cells, which can turn into virtually any cell type and potentially be used to treat disorders ranging from spinal cord injury to diabetes, could start within two years. (The Guardian – Nigeria)

March 6, 2013

Genetically corrected stem cells spark muscle regeneration

Researchers at the University of Minnesota’s Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD). (Science Daily)

Metro Detroit boy undergoes groundbreaking FDA stem cell trial for cerebral palsy

It’s a ground breaking new FDA trial. And a Metro Detroit boy is one of the first children in the world to participate in the procedure to treat his cerebral palsy with the use of cord blood stem cells. (CBS Local)

March 5, 2013

Devices aim to deliver on stem-cell therapies

Several laboratories are investigating ways to treat neurological diseases by injecting cells into patients’ brains, and clinical trials are being conducted for Parkinson’s disease, stroke and other neurodegenerative diseases. These studies follow experiments showing dramatic improvements in rats and mice. But as work on potentially therapeutic cells has surged ahead, necessary surgical techniques have lagged behind, says Lim. (Nature)

March 1, 2013

Stem cells aboard SpaceX will seed mice back on Earth

Stem cell research is taking off – literally. When the SpaceX Dragon capsule sets off for the International Space Station on 1 March, its cargo will include frozen embryonic stem cells – kick-starting a clever experiment that uses short-lived mice to investigate the human health effects of long-haul space flights. (New Scientist)

A New Issue of Human Reproduction is Available

A new issue of Human Reproduction (Vol. 28, No. 3, March 2013) is now available online and in print.

Articles of interest include:

February 28, 2013

Sweet news for stem cell’s ‘Holy Grail’

Researchers at the University of Manchester’s School of Materials and Faculty of Life Sciences have developed a web-like scaffold, coated with long-sugar molecules, that enhances stem-cell cultures to [become particular cell types]. The scaffold is formed by a process known as ‘electrospinning’, creating a mesh of fibres that mimic structures that occur naturally within the body. (Science Daily)

Stem cells cruise to clinic

In the seven years since their discovery, induced pluripotent stem (iPS) cells have transformed basic research and won a Nobel prize. Now, a Japanese study is about to test the medical potential of these cells for the first time. Made by reprogramming adult cells into an embryo-like state that can form any cell type in the body, the cells will be transplanted into patients who have a debilitating eye disease. (Nature)

February 26, 2013

Liver stem cells grown in culture, transplanted with demonstrated therapeutic benefit

But no lab in the world has been successful in identifying and growing liver stem cells in culture — using any available technique — until now. (Science Daily)

February 25, 2013

Placenta blood shows promise in stem-cell cancer treatment

One person in the U.S. is diagnosed with blood cancer every four minutes. Chemotherapy and a bone marrow transplant help fight off the disease, but thousands more diagnosed each year cannot find a matching donor. Now a solution using stem cells may be coming from a surprising place. (ABC)

Surprising science

Growing news hearts without using embryonic stem cells. (Smithsonian)

February 22, 2013

2013 induced pluripotent stem cells (iPSC) industry report – market trends, metrics, and financials

Bharat Book Bureau has recently added the market intelligence report titled “The Complete 2012-13 Induced Pluripotent Stem Cell Industry Report – Market Metrics, Dynamics, and Trends.” It provides strategic insights that guide the decision-making of companies that develop and manufacture induced pluripotent stem cell (iPSC) research products. (Wall Street Journal)

Stem cell ‘homing’ signal may help treat heart failure patients

In the first human study of its kind, researchers activated heart failure patients’ stem cells with gene therapy to improve their symptoms, heart function and quality of life, according to a study in the American Heart Association journal Circulation Research. Researchers delivered a gene that encodes a factor called SDF-1 to activate stem cells like a “homing” signal. (Medical Xpress)

February 19, 2013

Embryonic and induced pluripotent stem cells: Understanding, creating, and exploiting the nano-niche for regenerative medicine

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine. However, key to realizing this potential requires a strong understanding of stem cell biology, techniques to maintain stem cells, and strategies to manipulate cells to efficiently direct cell differentiation toward a desired cell type. (ACS Nano)

Stem cell-based bioartificial tissues and organs

Surgeon Paolo Macchiarini has made his name by successfully transplanting bioengineered stem cell-based trachea, composed of both artificial and biological material. He now plans to use the technique to recreate more complex tissues, such as the esophagus and diaphragm or organs such as the heart and lungs. (Science Daily)

 

The Bioethics Poll
Poll Results
How much may a suitable egg donor be paid for her eggs?
$5,000 39.0%
$5 25.9%
Any of the above 19.7%
$50,000 15.4%

Total votes: 615


 
 
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