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March 1, 2013

A New Issue of Human Reproduction is Available

A new issue of Human Reproduction (Vol. 28, No. 3, March 2013) is now available online and in print.

Articles of interest include:

February 28, 2013

Sweet news for stem cell’s ‘Holy Grail’

Researchers at the University of Manchester’s School of Materials and Faculty of Life Sciences have developed a web-like scaffold, coated with long-sugar molecules, that enhances stem-cell cultures to [become particular cell types]. The scaffold is formed by a process known as ‘electrospinning’, creating a mesh of fibres that mimic structures that occur naturally within the body. (Science Daily)

Stem cells cruise to clinic

In the seven years since their discovery, induced pluripotent stem (iPS) cells have transformed basic research and won a Nobel prize. Now, a Japanese study is about to test the medical potential of these cells for the first time. Made by reprogramming adult cells into an embryo-like state that can form any cell type in the body, the cells will be transplanted into patients who have a debilitating eye disease. (Nature)

February 26, 2013

Liver stem cells grown in culture, transplanted with demonstrated therapeutic benefit

But no lab in the world has been successful in identifying and growing liver stem cells in culture — using any available technique — until now. (Science Daily)

February 25, 2013

Placenta blood shows promise in stem-cell cancer treatment

One person in the U.S. is diagnosed with blood cancer every four minutes. Chemotherapy and a bone marrow transplant help fight off the disease, but thousands more diagnosed each year cannot find a matching donor. Now a solution using stem cells may be coming from a surprising place. (ABC)

Surprising science

Growing news hearts without using embryonic stem cells. (Smithsonian)

February 22, 2013

2013 induced pluripotent stem cells (iPSC) industry report – market trends, metrics, and financials

Bharat Book Bureau has recently added the market intelligence report titled “The Complete 2012-13 Induced Pluripotent Stem Cell Industry Report – Market Metrics, Dynamics, and Trends.” It provides strategic insights that guide the decision-making of companies that develop and manufacture induced pluripotent stem cell (iPSC) research products. (Wall Street Journal)

Stem cell ‘homing’ signal may help treat heart failure patients

In the first human study of its kind, researchers activated heart failure patients’ stem cells with gene therapy to improve their symptoms, heart function and quality of life, according to a study in the American Heart Association journal Circulation Research. Researchers delivered a gene that encodes a factor called SDF-1 to activate stem cells like a “homing” signal. (Medical Xpress)

February 19, 2013

Embryonic and induced pluripotent stem cells: Understanding, creating, and exploiting the nano-niche for regenerative medicine

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine. However, key to realizing this potential requires a strong understanding of stem cell biology, techniques to maintain stem cells, and strategies to manipulate cells to efficiently direct cell differentiation toward a desired cell type. (ACS Nano)

Stem cell-based bioartificial tissues and organs

Surgeon Paolo Macchiarini has made his name by successfully transplanting bioengineered stem cell-based trachea, composed of both artificial and biological material. He now plans to use the technique to recreate more complex tissues, such as the esophagus and diaphragm or organs such as the heart and lungs. (Science Daily)

February 14, 2013

Protein central to cancer stem cell formation provides new potential target

Researchers have identified a pivotal protein in a cellular transformation that makes a cancer cell more resistant to treatment and more capable of growing and spreading, making it an inviting new target for drug development. (Science Daily)

World’s first stem cell clinical trial one step closer to reality in Japan

Researchers in Japan are looking to use the recent discoveries of Nobel Prize winning Shinya Yamanaka to treat a degenerative eye disease in what would be the world’s first clinical trial of induced pluripotent stem cells (iPS cells). (Japan Daily Press)

Parents hopeful after daughter’s brain stem cell transplant

Attacked and left for dead by a man she had allegedly dated, the 24-year-old suffered serious brain damage more than a year ago. (WFAA)

Stem cells in Texas: Cowboy culture

By offering unproven therapies, a Texas biotechnology firm has sparked a bitter debate about how stem cells should be regulated. (Nature)

February 13, 2013

Researchers highlight warning signs on adult stem cell treatments

Three papers from the last year deal specifically with unexpected and adverse results of adult stem cell transplants. (Forbes)

February 12, 2013

Stem cell breakthrough could lead to new bone repair therapies on nanoscale surfaces

Scientists at the University of Southampton have created a new method to generate bone cells which could lead to revolutionary bone repair therapies for people with bone fractures or those who need hip replacement surgery due to osteoporosis and osteoarthritis. (Science Daily)

February 11, 2013

Research offers new hope for multiple sclerosis

Scientists have converted human skin cells into brain cells and used them to treat mice with myelin disorders, a family of diseases that includes multiple sclerosis. (Wall Street Journal)

Unethical stem cells?

Some of the 200 or so human embryonic stem cell lines approved for federal funding may have been derived from sperm or eggs of unconsenting donors. (The Scientist)

February 8, 2013

Protein paves the way for correct stem cell differentiation

Research from BRIC, University of Copenhagen, has identified a crucial role of the molecule Fbxl10 in differentiation of embryonic stem cells and suggests the molecule as a new potential target for cancer therapy. (Science Daily)

February 6, 2013

Trigger turns muscles stem cells into fat: Discovery identifies potential obesity treatment

Ottawa scientists have discovered a trigger that turns muscle stem cells into brown fat, a form of good fat that could play a critical role in the fight against obesity. (Science Daily)

February 5, 2013

Scientists use 3-D printer to speed human embryonic stem cell research

Researchers have been able to engineer tissue samples in the past by combining artificial scaffold-like structures and animal cells. Depositing human embryonic stem cells in cultures using a 3-D printer offers some advantages. In particular, the cells can be positioned in droplets of uniform size cheaper, faster and more easily than using manual methods. This uniformity is important for researchers trying to generate specific cell types. (Scientific American)

 

The Bioethics Poll
Poll Results
How much may a suitable egg donor be paid for her eggs?
$5,000 39.0%
$5 25.9%
Any of the above 19.7%
$50,000 15.4%

Total votes: 615


 
 
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