Organoids Grown from Amniotic Fluid Could Shed Light on Rare Diseases

March 5, 2024

digitally enhanced image of an embryo

(Nature) – Cells taken from the fluid around growing fetuses have been used to make organoids, 3D bundles of cells that mimic tissue. These organoids could help researchers to understand diseases that develop in the fetus during pregnancy.

The researchers grew organoids from lung, kidney and small intestine cells shed into amniotic fluid collected from 12 pregnancies between the 16th and 34th weeks of gestation. This is the first time that organoids have been grown directly from cells taken from ongoing pregnancies, says Mattia Gerli, a stem-cell biologist at University College London and a co-author of the study, which is published in Nature Medicine. (Read More)