(Wired) – Cultivators are turning to genetic sequencing and cellular-manipulation techniques to breed highly potent mushrooms—leaving some unprepared psychonauts in distress.

New cultivation methods are making psychedelic mushrooms stronger, and fiendishly potent varieties are kicking in faster and lasting longer—even if you eat only a fraction of what you would with another variety. Subsequent testing showed that one batch of Mattucci’s mushrooms contained almost 5 percent psychedelic alkaloids, which was once unheard of within the Psilocybe genus. Typically, mushrooms contain 1 percent of these psychoactive compounds, although species like Psilocybe azurescens are generally stronger, and some varieties within the Panaeolus genus are even more potent. (Read More)