The Science and Ethics of Human/Animal Chimera Research

April 12, 2019

May 16, 2019 @ 5:00 pm – 6:30 pm
Harvard Medical School, TMEC 227
260 Longwood Avenue Boston
MA 02115
Harvard Medical School Center for Bioethics

Stem cell-based human/animal chimera research involves the transfer of human stem cells into animal hosts at various stages of development. The purpose of this research is to introduce localized human biological characteristics into laboratory animals to advance stem cell science, developmental biology, and many areas of biomedicine.

Human/animal chimera research has existed without much controversy for decades outside of stem cell research, resulting in, for example, mouse models of human cancer and the human immune system. However, the possibility of acute levels of human/animal mixing in stem cell-based chimeras is of special concern.

Insoo Hyun and Willy Lensch will discuss the scientific and ethical issues raised by stem cell-based chimera research, drawing on years of Dr. Lensch’s chimera research experience and Dr. Hyun’s published work and externally funded bioethics research in this area.


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