(MedPage Today) – The bacillus Calmette-Guérin (BCG) vaccine, commonly used against tuberculosis, changed how immune cells behaved and altered markers linked to Alzheimer’s disease in a pilot study involving two open-label trials.

In a year-long study, BCG vaccination induced persistent, trained immunity-like changes in cerebrospinal fluid (CSF), including enhanced innate immune responsiveness, reported Steven Arnold, MD, of Massachusetts General Hospital in Boston, and co-authors in Communications Medicine. (Read More)