Customized DNA Rings Aid Early Cancer Detection in Mice, Study Finds

February 24, 2015

(Medical Xpress) – Stanford University School of Medicine investigators administered a customized genetic construct consisting of tiny rings of DNA, called DNA minicircles, to mice. The scientists then showed that mice with tumors produced a substance that tumor-free mice didn’t make. The substance was easily detected 48 hours later by a simple blood test. A paper describing the findings of this proof-of-principle study will be published online Feb. 23 in the Proceedings of the National Academy of Sciences.