Harvard Scientists Develop Cas9-Based Method to Reprogram Gene Expression

March 9, 2015

(Genome Web) – Researchers from Harvard University have leveraged the Cas9 protein to activate genes, causing them to activate transcription to express or repress desired genetic traits. By fusing the Cas9 nuclease to a hybrid triple-strength transcription factor, the scientists from the Wyss Institute at Harvard University and Harvard Medical School further were able to manipulate multiple genes to control expression, they reported in a paper published this week inĀ Nature Methods.