Replications, Ridicule and a Recluse: The Controversy Over NgAgo Gene-Editing Intensifies

August 8, 2016

(Nature) – A controversy is escalating over whether a gene-editing technique proposed as an alternative to the popular CRISPR–Cas9 system actually works. Three months ago, Han Chunyu, a biologist at Hebei University of Science and Technology in Shijiazhuang, reported that the enzyme NgAgo can be used to edit mammalian genes. Now, an increasing number of scientists are complaining that they cannot replicate Han’s results — although one has told Nature that he can.