Male Contraceptive Could Be Near as Trial of Gel Begins

June 24, 2019

(The Guardian) – The gel, which is applied daily to the chest, shoulders and upper arms, contains a mixture of progesterone and testosterone. The progesterone switches off sperm production in the testes and the testosterone offsets a drop in testosterone that this causes. Without adding testosterone back in, men get unpleasant side-effects such as low mood, weight gain and a slump in libido. Because testosterone is metabolised so quickly in the liver, it can’t be delivered effectively via a pill, and this has proved the major obstacle to developing a male hormonal contraceptive.