How to Supercharge Cancer-Fighting Cells: Give Them Stem Cell Skills

April 10, 2024

purple cells on a green medium

(Nature) – Bioengineered immune cells have been shown to attack and even cure cancer, but they tend to get exhausted if the fight goes on for a long time. Now, two separate research teams have found a way to rejuvenate these cells: make them more like stem cells. Both teams found that the bespoke immune cells called CAR T cells gain new vigour if engineered to have high levels of a particular protein. These boosted CAR T cells have gene activity similar to that of stem cells and a renewed ability to fend off cancer. Both papers were published today in Nature. (Read More)