Human Brain Organoids Develop Optic Vesicles, Respond to Light

August 20, 2021

(GEN News) – Brain organoids have helped unravel the understanding of cellular diversities, complex interactions, and neuronal networks. Human-induced pluripotent stem cells (iPSCs) can be used to generate brain organoids containing the optic cup—a structure that gives rise to the retina. Now, new research shows that the optic vesicle-containing brain organoids (OVB organoids) develop bilaterally symmetric optic vesicles and are light sensitive. The research team behind the work plans to develop strategies to keep the optic cups viable for long time periods, using them to investigate mechanisms that cause retinal disorders. (Read Full Article)