Nanoparticle Trafficking in the Central Nervous System

May 2, 2014

(Nanowerk) – Prevention and treatment of neurological disorders in humans – such as for example Parkison’s disease, Alzheimer’s disease, Huntington disease, multiple sclerosis and brain tumors – necessitate delivery of therapeutic or neuroprotective agents across the so-called blood-brain barrier (BBB) into the brain. This barrier, a tight seal of endothelial cells that lines the blood vessels in the brain, is a physiological checkpoint that selectively allows the entry of certain molecules from blood circulation into the brain.