Historic decline in U.S. overdose deaths threatened by changing street drug supply

April 15, 2026

beakers and other laboratory glassware

(NPR) – Where once most drug users mostly consumed plant-based substances such as cocaine and heroin, drug gangs and cartels have shifted to producing and selling synthetic substances made from industrial chemicals.

Fentanyl and methamphetamines have been around for years. Now, illicit chemists are adulterating batches of street drugs with a fast-changing and often baffling mix of compounds, ranging from Novocaine to a stabilizer used in plastics manufacturing called BTPMS. (Read More)