A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation

September 26, 2012

Somatic cells can be reprogrammed to form embryonic stem cell-like induced pluripotent stem cells (iPSCs), but the process suffers from low efficiency and the underlying molecular mechanisms that control reprogramming remain poorly understood. Here we perform an inhibitor screen to identify kinases that enhance, or present a barrier to, reprogramming. (Nature Communications)