Beyond CRISPR: A Guide to the Many Other Ways to Edit a Genome

August 8, 2016

(Nature) – The zeal with which researchers jumped on a possible new gene-editing system called NgAgo earlier this year reveals an undercurrent of frustration with CRISPR–Cas9 — and a drive to find alternatives. “It’s a reminder of how fragile every new technology is,” says George Church, a geneticist at Harvard Medical School in Boston, Massachusetts.  NgAgo is just one of a growing library of gene-editing tools. Some are variations on the CRISPR theme; others offer new ways to edit genomes.