With Mini-Placentas and Mini-Brains, Scientists Try to Unravel the Roots of Psychiatric Disorders

July 31, 2019

(STAT News) – Biologist Jennifer Erwin of the Lieber Institute for Brain Development, however, has no intention of babying her organoids: the world’s first human placentas in a dish that were made from stem cells. Challenging as the half-millimeter-across organoids were to create, she intends to starve them of oxygen and douse them with stress hormones, among other assaults. It’s all for a good cause: to mimic pregnancy complications that raise the risk of brain development going off the rails, resulting in conditions including schizophrenia, autism, attention deficit hyperactivity disorder, and intellectual disability.

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