(Science) – A cutting-edge gene-editing trial in China went disastrously wrong. A family wants accountability

Although news that base editing saved “Baby KJ” would soon rocket around the world—Science named the feat one of the runners-up for its 2025 Breakthrough of the Year—the story of what happened at Xinhua Hospital has remained hidden. An entry for the study posted to ClinicalTrials[dot]gov has not been updated for more than a year. And when Qiu and his colleagues published proof-of-concept animal studies related to the trial in Nature early this year, they stripped the paper of references to the family and its financial contributions, noting only that “bridging the gap between preclinical research and clinical translation remains a significant challenge.”

That vague language glossed over tragedy: Seven days after the girl’s medical team infused trillions of viruses carrying the recipe for the base editor into her spinal fluid, she died of a severe immune reaction linked to the therapy, Science and Retraction Watch can now reveal. (Read More)