Building a Defense-in-Depth Biosecurity Strategy for the AI Era
August 21, 2026

(RAND) – The convergence of artificial intelligence (AI) and biology offers great promise for medicine and public health, including the potential to yield transformative societal benefits. Yet this same convergence could introduce serious global health and national security risks. As capabilities continue to advance, AI-enabled biotechnology might lower the technical, operational, and motivational barriers to creating biological weapons. It might also enable high-consequence attacks involving enhanced or novel pathogens. The dual-use nature of biotechnology requires proactive mitigation measures to counter these threats.
In this report, the authors develop a defense-in-depth mitigation strategy that is robust, complementary, and deployable across a wide variety of threat scenarios. (Read More)