‘Smart’ Nanoparticles Deliver mRNA Directly to Tumors in New Cancer Therapy
September 18, 2026

(Wired) – The treatment can reprogram immune cells that have been corrupted by the cancer, strengthening the body’s ability to attack.
In a study published this week in Science Advances, Zhao’s team developed a system that can precisely deliver an mRNA therapy to transform immune cells back into allies. The researchers focused on tumor-associated macrophages, which—when rewired by signals from the cancer—hinder the arrival and activity of T cells, one of the body’s main weapons against cancer. The mRNA carries the instructions for producing CXCL9, a chemical signal for recruiting T cells. (Read More)