Oliver Smithies (1925-2017)

February 8, 2017

(Nature) – Oliver Smithies had a habit of inventing ways to do the experiments he wanted to do, and crafted tools that are now used widely in biology. He won the Nobel Prize in Physiology or Medicine in 2007 for developing methods to genetically modify individual mammalian genes. His work provided the means to modify any gene in mouse embryonic stem cells. This approach, known as gene targeting, has been used to create thousands of lines of mice carrying desired genetic mutations.