A devastating nerve disease stalks a mountain village

December 23, 2024

MRI images of the brain

(Knowable Magazine) – Neurologists have grappled with a cluster of amyotrophic lateral sclerosis cases in France, where a fondness for a toxic wild mushroom may hold the answer

Well known to skiers and alpinistes, Montchavin also has grabbed the attention of medical researchers as the site of a highly unusual cluster of a devastating neurological disease, amyotrophic lateral sclerosis.

ALS, brought about by the progressive loss of nerve function in the brain, spinal cord and motor neurons in the limbs and chest, leading to paralysis and death, is both rare and rather evenly distributed across the globe: It afflicts two to three new people out of 100,000 per year. Though Montchavin is flooded with visitors in winter and summer, the year-round resident population is only a couple hundred, and neighboring villages aren’t much bigger, so the odds are strongly against finding more than just a few ALS patients in the immediate area. Yet physicians have reported 14. (Read More)